After a recent Windows 10 update, suddenly Paint Tool Sai (I use Sai 2 specifically) would not open any more.
No error message would come up in any form and nothing would even register in Task Manager. There was simply the "loading circle" beside the mouse for a moment after clicking on the software, then nothing.
Other fixes for Sai not running in Windows suggest to run the software in compatibility mode for different versions, and to try each of those both with and without running as administrator. These did not work in my case, and if you find yourself in a similar situation, below is the fix I finally found.
I must, however, give the